I think Murakami's genius is simplified by many observers in the current wash of anime-aesthetic hitting US shores. His visions manage time after time to be more compelling and interesting than the vast majority of commercial cash-ins on the anime boom.
I saw a display of his work at the Little Tokyo branch of the LACMA two years ago. His designs border on the psychadelic but manage to incorporate a bubbly, cute anime/cartoon feel that makes them digestible. I especially enjoyed how he takes the exaggerations of women and sexuality in anime aesthetics to the extreme conclusion. (see: "Hiropon")